Matteo G Della Porta Principal Investigator View More
- AddressVia Manzoni, 56 - 20089 Rozzano - Milan, Italy
- Phone+39 02 8224 7668
- Fax+39 02 8224 4592
Current research interests mainly concern myeloid neoplasms (MN, myelodysplastic syndromes, acute myeloid leukemias, myeloproliferative neoplasms) We are studying the molecular architecture of these diseases by using next-generation sequencing approaches, with the aim to:
– define relationships between genotype and disease phenotype as a basis for a molecular classification of NM
– define innovative prognostic tools, including a reliable diagnostic approach to familial disorders with inherited predisposition to MN
– develop novel genotype-based clinical decision-making models for MN and define predictive biomarkers to better stratify the individual probability of response to specific treatments.
Study of clonal hematopoiesis in elderly people
we aim to characterize by next generation sequencing analysis how clonal hematopoiesis relates to the induction of MN clinical phenotype and disease evolution, as well as to test the potential utility of targeted gene sequencing as screening method to detect patients at risk of developing MN. The development of therapeutic interventions aimed at the eradication of clones harboring the genetic aberrations that accumulate in hematopoietic stem cells is expected to provide effective cancer prevention in next future.
Personalised medicine programs in MN
We aim to define (by using decision models, Bayesian network analysis and artificial intelligence approaches) effective clinical/molecular prognostic systems in MN and to define predictive biomarkers to better stratify the individual probability of response to specific treatments. Reaching these objectives would substantially improve the management of MN through the development of personalized treatment strategies.
Matteo Della Porta Publications
Selected Publications: 20-25 publications listed in details with all the contributing authors, title of the papers, journal, dates. 1) Della Porta MG, Jackson CH, Alessandrino EP, Rossi M, Bacigalupo A, ...
Marilena Bicchieri Post Doctoral Fellow View More
Chiara Chiereghin Post Doctoral Fellow View More
Matteo Zampini PhD View More
Marta Ubezio MD View More
Erica Travaglino View More
Elena Saba PhD View More
Marianna Rossi MD View More
Lucio Morabito MD View More
Chiara Milanesi PhD View More
Nicla Manes PhD View More