Short-bio

Carolina Greco is assistant professor at Humanitas University and staff scientist at Humanitas Research Hospital, in Milan, where she leads her research projects within the Inflammation and Immunology in Cardiovascular Pathologies Lab headed by Gianluigi Condorrelli.

Greco obtained her Ph.D. in Translational and Molecular Medicine (DIMET) from the University of Milan Bicocca, Italy in 2015. She then joined the Center for Epigenetics and Metabolism directed by Prof. Paolo Sassone-Corsi at the University of California, Irvine (UCI) where she studied the molecular mechanisms linking metabolism, epigenetics and the circadian clock. She moved back to Italy in 2021 under the MSCA scheme, that funded the MetEpiClock research project, and currently she is Assistant Professor at Humanitas University.

Her research focuses on circadian biology and metabolism in cardiovascular disease, mainly heart failure (HF). Using experimental models of HF, she aims to elucidate how metabolism intersects with the epigenetic landscape of the failing heart and how the heart affects metabolism in peripheral tissues to alter disease progression.

Selected publications

Carolina M. Greco#,*, Kevin B. Koronowski,*, Jacob G. Smith*, Jiejun Shi, Siwei Chen, Muntaha Samad, Patrick-Simon Welz, Valentina M. Zinna, Thomas Mortimer, Kohei Shimaji, Tomoki Sato, Paul Petrus, Shoko Sato, Cassandra Van, Jose Manual Monroy Kuhn, Kenneth A. Dyar, Dominik Lutter, Marcus M. Seldin, Wei Li, Pierre Baldi, Salvador Aznar Benitah#, Paolo Sassone-Corsi Integration of Feeding Behavior by the Liver Circadian Clock Reveals Network Dependency of Metabolic Rhythms Science Advances2021 24;7(39) # corresponding author; *These authors contributed equally

Kevin B. Koronowski*#, Carolina M. Greco*#, He Huang, Jin-Kwang Kim, Rachel Fellows, Jennifer Fribourgh, Lavina Mathur, Xuelian Ren, Carrie L. Partch, Cholsoon Jang, Feng Qiao, Yingming Zhao, Paolo Sassone-Corsi, Ketogenesis Impact on Liver Metabolism Revealed by Proteomics of Lysine β-hydroxybutyrylation Cell Reports 2021 3;36(5):109487 # corresponding author; * These authors contributed equally

Sato S, Greco CM*, Expanding the link between circadian rhythms and redox metabolism of epigenetic control. Free Radic Biol Med. 2021 170:50-58 * Corresponding Author

Greco CM*, Cervantes M, Fustin JM, Ceglia N, Samad M, Shi J, Forne I, Imhof A, Li w, Baldi P, Okamura H, Sassone-Corsi P*, S-Adenosyl-L-Homocysteine Hydrolase Links Methionine Metabolism to the Circadian Clock and Chromatin Remodeling. Science Advances 2020 6(51):eabc5629 * Corresponding Author

Greco CM, Garetto S, Motellier E, Liu Y, Chen S, Baldi P, Sassone-Corsi P*, Lucci J*. A nonpharmacological therapeutic approach in the gut triggers distal metabolic rewiring capable of ameliorating diet-induced dysfunctions encompassed by metabolic syndrome. Sci Rep 2020 10(1):12915

Greco CM, Sassone-Corsi P. (2020) Personalized medicine and circadian rhythms: Opportunities for modern society. J Exp Med. 217(6):e20200702

Greco CM, Sassone-Corsi P. (2019) Circadian Blueprint of Metabolic Pathways in the Brain. Nat. Rev. Neuroscience 20(2):71-82

Greco CM*, Kunderfranco P, Rubino M, Larcher V, Carullo P, Anselmo A, Kurz K, Carell T, Angius A, Latronico MV, Papait P, Condorelli G*. DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy Nature Communications 2016 7:12418 * Corresponding Author

Greco CM, Condorelli G. Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure. Nature Reviews Cardiology 2015 12(8):488-97

Greco CM, Camera M, Facchinetti L, Brambilla M, Pellegrino S, Gelmi ML, Tremoli E, Corsini A, Ferri N. Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptor. Cardiovasc Res. 2012 95(3):3667-4