The overall goal of our research activity is to contribute to the understanding of molecular and cellular mechanisms acting in the pathophysiology of the bone tissue. Our specific objectives are the elucidation of the etiopathogenesis of rare and common skeletal diseases through studies in patients and mouse models, and the development of new therapeutic strategies in preclinical models by using recombinant proteins, cell-based approaches (MSC, iPSC) as well as gene editing and gene therapy approaches.
Rare skeletal diseases: investigation of the genetic basis of the disease through NGS technologies, approaches of classical molecular biology, in vitro studies with primary and established cell lines, animal models. Specific focus on Autosomal Recessive Osteopetrosis (ARO) and AFFND1.
Focus on the RANKL cytokine: investigation of possible new functions beyond the essential pro-osteoclastogenic role.
Oxidative stress in the pathogenesis and resolution of osteoimmunological conditions: elucidation of the role and possible exploitation of new molecular players.
Regenerative medicine for the bone tissue exploiting soluble factors, in vitro-corrected cells, biomimetic scaffolds.
-
Cristina Sobacchi Publications
Selected Publications: 20-25 publications listed in details with all the contributing authors, title of the papers, journal, dates. Menale C, Robinson LJ, Palagano E, Rigoni R, Erreni M, Almarza AJ, ...
