Marianna Paulis graduated from the University of Pavia in 2000. She received her PhD in Genetics and Molecular Science in 2004. Since 2006 she has been working at the National Research Council (CNR) of Milan with a post-doctoral position. In 2015, she obtained a tenured position at the CNR of the Institute of Genetic and Biomedical Research based in Milan.

Dr. Paulis has acquired substantial experience and expertise in the field of classical and molecular cytogenetic of mammalian cells and years of experience in mouse and human stem cell biology. Her main interest is in the investigation of gene therapy approaches for genome disorders due to chromosomal abnormalities. She obtained mouse embryonic stem cells (ESCs) in which a sex chromosome was perfectly substituted with an exogenous one, providing the first corrected diploid cell with chromosome transplantation. A recent important part of her research has been focused on the use of the CRISPR/Cas9 technology in ESCs to induce the correction of recessive genetic defects by the endogenous repair machinery. Currently, her main activity is the generation and corrections of induced pluripotent stem cells (iPSCs) from patients affected by genetic diseases.