I obtained a PhD in Immunology from the University Modena and Reggio Emilia, Italy, under the supervision of Prof. Andrea Cossarizza where I studied T cell immune responses and homeostasis during the course of Human Immunodeficiency Virus (HIV) infection. I then moved to the Vaccine Research Center at the National Institutes of Health in Bethesda, MD, USA to join the ImmunoTechnology Section directed by Dr. Mario Roederer. There, I studied the molecular mechanisms involved in the maintenance of long-lived T cell immunity in humans and nonhuman primates. In collaboration with Dr. Thomas Waldmann, I moved Interleukin (IL)-15, a cytokine capable of activating anti-tumor effector cells, from the preclinical level to the first-in-human phase I clinical trial in patients with solid cancers. After a brief period as a senior scientist under the supervision of Prof. Domenico Mavilio, I obtained an independent position as the principal investigator of the Laboratory of Translational Immunology and as head of the Humanitas flow cytometry core. My research is funded by a Starting Grant from the European Research Council, the Associazione Italiana per la Ricerca sul Cancro e by the Italian Ministry of Health.