Education

1980: Degree in Biological Sciences “Magna cum Laudae”, University of Pavia – Pavia – Italy

1983: PhD Pharmacological research.

Professional experience

1981-1984: Research fellow, Laboratory of Human immunology, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy.

1983: Visiting Fellow – Department of Bacteriology and Immunology, Western Infirmary, Glasgow, UK.

1985-1986: Guest Worker – Laboratory of Molecular Immunoregulation, National Institute of Health, Frederick Cancer Research Facility, Frederick, MD, USA.

2003: Visiting Scientist – Sir William Dunn School of Pathology, University of Oxford, UK.

1986-2005: Research assistant, Laboratory of Human immunology, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy.

2005-2007: Research assistant, Research Laboratory in Immunology & Inflammation, Humanitas Clinical and Research Center, Rozzano (MI), Italy.

2007: Visiting Scientist – Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

2007  to date: Group Leader, Laboratory of Immunopharmacology, Humanitas Clinical and Research Center, Rozzano (MI), Italy.

 

Research interests

Main interest in the field of Innate Immunity

  • Long Pentraxin PTX3: expression and purification of the recombinant protein; definition of biochemical and structural properties; characterization of PTX3 interactome, with identification of new ligands, mapping of the domains involved in the recognition and relevance for the biological properties of PTX3 in the context of innate immune response to pathogens and regulation of inflammation; validation of the role of PTX3 as diagnostic and prognostic marker in human pathologies and development as possible therapeutic agent in selected infections.
  • New markers of macrophage polarization: generation of original reagents (recombinant proteins; monoclonal antibodies); characterization of the biological properties (motogenic activity, tumor growth; angiogenesis); prognostic value of new markers exprrssed by M2-like tumor-associated macrophages (TAM).

Research activity is documented by more than 150 publications in international peer reviewed journals, more than 20 chapters on scientific books, several abstracts at congresses. Reviewer ad hoc for the following journals: Front Immunol, Haematologica, Int. J. Vascular Medicine, Int. J. Endocrinology, J. Nephrology, J. Reumathology, J. COPD, PLOSone.