Selected Publications:

Adaptive immunity in Cardiovascular Disease

Martini E, Cremonesi M, Panico C, Carullo P, Bonfiglio CA, Serio S, Jachetti E, Colombo MP, Gianluigi Condorelli G* and Kallikourdis M* (2020) Circulation Res T Cell Costimulation Blockade Blunts Age-Related Heart Failure (in press) doi: 10.1161/CIRCRESAHA.119.316530 (*:corresponding authors)

F Bonacina, E Martini, M Svecla, J Nour, M Cremonesi, G Beretta, A Moregola, F Pellegatta, V Zampoleri, AL Catapano, M Kallikourdis* and GD Norata* (2020) Adoptive transfer of CX3CR1-transduced T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression Cardiovascular Research (in press) (*:co-last authors)

Martini E, Kunderfranco P, Peano C, Carullo P, Cremonesi M, Schorn T, Carriero R, Termanini A, Colombo FS, Jachetti E, Panico C, Faggian G, Fumero A, Torracca L, Molgora M, Cibella J, Pagiatakis C, Brummelman J, Alvisi G, Mazza EMC, Colombo MP, Lugli E, Condorelli G*, Kallikourdis M*. (2019) Single cell sequencing of mouse heart immune infiltrate in pressure overload-driven heart failure reveals extent of immune activation Circulation doi: 10.1161/CIRCULATIONAHA.119.041694.)

Perego C, Fumagalli S, Miteva K, Kallikourdis M, De Simoni MG (2019) Combined genetic deletion of Th2 cytokines does not affect ischemic injury in mice Stroke 2019 Aug;50(8):2207-2215. doi: 10.1161/STROKEAHA.119.025196.

Kallikourdis M*, Martini E, Carullo P, Sardi C, Roselli G, Greco C, Vignali D, Riva F, Ormbostad Berre AM, Stølen TO, Fumero A, Faggian G, Di Pasquale E, Elia L, Rumio C, Catalucci D, Papait R, Condorelli G* (2017). T cell costimulation blockade blunts pressure overload-induced heart failure. Nature Communications. doi: 10.1038/ncomms14680 (*:corresponding and senior authors)

Martini E, Stirparo GG, Kallikourdis M* (2017) Immunotherapy for cardiovascular disease. J Leuk Biol doi 10.1002/JLB.5MR0717-306R (*:corresponding author)

Garetto S, Trovato AE, Sala F, Lleo A, Martini E, Betz AG, Norata GD, Invernizzi P and Kallikourdis M* (2015) Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment. Immunobiology 220(8), 1025-1029. doi: 10.1016/j.imbio.2015.02.006. (*:corresponding author)

 

Adaptive immunity in Cancer

Martini E, Giugliano S, Rescigno M, Kallikourdis M*. (2020) Regulatory T Cells Beyond Autoimmunity: From Pregnancy to Cancer and Cardiovascular Disease Front Immunol. 11:509. doi: 10.3389/fimmu.2020.00509. eCollection 2020. (*:corresponding author)

Kallikourdis M (2018) T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy. Cancer Immunol Immunother (in press)

Vignali D, Kallikourdis M* (2017) Improving homing in T cell therapy. Cytokine Growth Factor Rev.36:107-116

Garetto S, Sardi C, Martini E, Roselli G, Morone D, Angioni R, Cianciotti BC, Trovato AE, Franchina DG, Castino GF, Vignali D, Erreni M, Marchesi F, Rumio C and Kallikourdis M* (2016) Tailored chemokine receptor modification improves homing of adoptive therapy T cells in a spontaneous tumor model. Oncotarget 7(28), 43010-43026. doi: 10.18632/oncotarget.9280. (*:corresponding author)

Garetto S, Sardi C, Morone D and Kallikourdis M* (2016) Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors. Book Chapter in Springer Volume: Defects in T cell Trafficking and Resistance to Cancer, edited by Emmanuel Donnadieu p.163-178. doi: 10.1007/978-3-319-42223-7 (*:corresponding author)

 

Adaptive immunity (general)

Kallikourdis M, Trovato AE, Roselli G, Muscolini M, Porciello N, Tuosto L and Viola A. (2016) Phosphatidylinositol 4-phosphate 5-kinase β controls recruitment of lipid rafts into the immunological synapse J Immunol 196:1955. doi: 10.4049/jimmunol.1501788

Tortarolo M, Vallarola A, Lidonicci D, Battaglia E, Gensano F, Spaltro G, Fiordaliso F, Corbelli A, Garetto S, Martini E, Pasetto L, Kallikourdis M, Bonetto V and Bendotti C (2015) Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression. Journal of Neurochemistry. 135(1): 109-24. doi: 10.1111/jnc.13154

Kallikourdis M, Viola A and Benvenuti F (2015) Human immunodeficiencies related to defective APC/T cell interaction. Front. Immunol. 6:433. doi: 10.3389/fimmu.2015.00433

Kallikourdis M*, Trovato AE, Anselmi F, Sarukhan A, Roselli G, Tassone L, Badolato R and Viola A (2013) The CXCR4 mutations in WHIM syndrome impair the stability of the T cell immunological synapse. Blood.122:666-73. (*:corresponding author)

 

Adaptive Immunity and pregnancy

Benedusi V, Martini E, Kallikourdis M, Villa A, Meda C and Maggi A (2015) Ovariectomy shortens the life span of female mice. Oncotarget 6(13), 10801-10811.

Suano AM*, Kallikourdis M*, Sarris M* and Betz AG, (2012) Regulatory T cells protect from autoimmune arthritis during pregnancy, J Autoimmunity 38, J103-8. (*=contributed equally)

Terness P, Kallikourdis M, Betz AG, Rabinovich GA, Saito S & Clark DA (2007) Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells. Am J Reprod Immunol 58, 238-254.

Kallikourdis M, Betz AG (2007) Periodic Accumulation of Regulatory T Cells in the Uterus; Preparation for the Implantation of a Semi-Allogeneic Fetus? PLoS ONE 2, e382.

Kallikourdis M, Andersen K, Welch K & Betz AG (2007) Alloantigen-Enhanced Accumulation of CCR5+ ‘Effector’ Regulatory T Cells in the Gravid Uterus. Proc Natl Acad Sci U S A 104, 594-599.

Aluvihare VR, Kallikourdis M & Betz AG (2005) Tolerance, Suppression and the Fetal Allograft. J Mol Med 83, 88-96.

Aluvihare V, Kallikourdis M & Betz A (2004) Regulatory T Cells Mediate Maternal Tolerance to the Fetus. Nat Immunol 5, 266-271.

Bystry RS, Aluvihare V, Welch KA, Kallikourdis M & Betz AG (2001) B Cells and Professional APCs Recruit Regulatory T Cells Via CCL4. Nat Immunol 2, 1126-1132.