Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Costa G, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, De Simone G, Tufano M, Aghemo A, Di Tommaso L, Peano C, Cibella J, Iannacone M, Roychoudhuri R, Manzo T, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, and Lleo A. Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target. J Hepatol. 2022 Jun 20;S0168-8278(22)00370-1.
Zehn D, Thimme R, Lugli E, de Almeida GP, and Oxenius A. ‘Stem-like’ precursors are the fount to sustain persistent CD8(+) T cell responses. Nat Immunol. 2022 Jun;23(6):836-847.
Galletti G, De Simone G, Mazza EMC, Puccio S, Mezzanotte C, Bi TM, Davydov AN, Metsger M, Scamardella E, Alvisi G, De Paoli F, Zanon V, Scarpa A, Camisa B, Colombo FS, Anselmo A, Peano C, Polletti S, Mavilio D, Gattinoni L, Boi SK, Youngblood BA, Jones RE, Baird DM, Gostick E, Llewellyn-Lacey S, Ladell K, Price DA, Chudakov DM, Newell EW, Casucci M, and Lugli E. Two subsets of stem-like CD8(+) memory T cell progenitors with distinct fate commitments in humans. Nat Immunol. 2020. Dec;21(12):1552-1562.
Alvisi G, Brummelman J, Puccio S, Mazza EM, Tomada EP, Losurdo A, Zanon V, Peano C, Colombo FS, Scarpa A, Alloisio M, Vasanthakumar A, Roychoudhuri R, Kallikourdis M, Pagani M, Lopci E, Novellis P, Blume J, Kallies A, Veronesi G, and Lugli E#. IRF4 instructs effector Treg differentiation and immune suppression in human cancer. J Clin Invest. 2020;130(6):3137-50.
Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, Wherry EJ, Youngblood BA, Zehn D. Defining ‘T cell exhaustion’. Nat Rev Immunol. 2019 Nov;19(11):665-674.
Pilipow, K., Scamardella, E., Puccio, S., Gautam, S., De Paoli, F., Mazza, E. M., De Simone, G., Polletti, S., Buccilli, M., Zanon, V., Di Lucia, P., Iannacone, M., Gattinoni, L. & Lugli, E. Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity. JCI insight 2018 Sep 20;3(18):e122299.
Brummelman, J., Mazza, E. M. C., Alvisi, G., Colombo, F. S., Grilli, A., Mikulak, J., Mavilio, D., Alloisio, M., Ferrari, F., Lopci, E., Novellis, P., Veronesi, G. & Lugli, E. High-dimensional single cell analysis identifies stem-like cytotoxic CD8(+) T cells infiltrating human tumors. J Exp. Med. 2018 Oct 1;215(10):2520-2535.
Roberto, A., Castagna, L., Zanon, V., Bramanti, S., Crocchiolo, R., McLaren, J. E., Gandolfi, S., Tentorio, P., Sarina, B., Timofeeva, I., Santoro, A., Carlo-Stella, C., Bruno, B., Carniti, C., Corradini, P., Gostick, E., Ladell, K., Price, D. A., Roederer, M., Mavilio, D. & Lugli, E. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 2015 Apr 30;125(18):2855-64.
Conlon, K. C., Lugli, E., Welles, H. C., Rosenberg, S. A., Fojo, A. T., Morris, J. C., Fleisher, T. A., Dubois, S. P., Perera, L. P., Stewart, D. M., Goldman, C. K., Bryant, B. R., Decker, J. M., Chen, J., Worthy, T. A., Figg, W. D., Sr., Peer, C. J., Sneller, M. C., Lane, H. C., Yovandich, J. L., Creekmore, S. P., Roederer, M. & Waldmann, T. A. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin. Oncol. 2015 Apr 30;125(18):2855-64.
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., Wang, E., Douek, D. C., Price, D. A., June, C. H., Marincola, F. M., Roederer, M. & Restifo, N. P. A human memory T cell subset with stem cell-like properties. Nat Med. 2015 Apr 30;125(18):2855-64.