Mavilio Selected Publications

Carenza C.#, Franzese S.#, Castagna A., Terzoli S., Simonelli M., Persico P., Bello L., Nibali M.C., Pessina F., Kunderfranco P., Peano C., Balin S., Mikulak J., Calcaterra F., Bonecchi R., Savino B., Locati M., Della Bella S.#*, Mavilio D.#* Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas. Frontiers in Immunology, 2023 Jan 10;13:1074762.

Van Beek J.J.P., Puccio S., Di Vito C., De Paoli F., Zaghi E., Calvi M., Scarpa A., Peano C., Basso G., Cibella J., De Philippis C., Sarina B., Timofeeva I., Capizzuto R., Mannina D., Mineri R., Mariotti J., Crocchiolo R., Santoro A., Castagna L., Bramanti S., Mavilio D., Lugli E. Selected memory T cells infused post haploidentical hematopoietic stem cell transplantation persist and hyper-expand. Blood Advances, 2022 Dec 5;bloodadvances.2022007735.

Bruni E., Cimino M.M., Donadon M., Carriero R., Terzoli S., Piazza R., Ravens S., Prinz I., Cazzetta V., Marzano P., Kunderfranco P., Peano C., Soldani C., Franceschini B., Colombo F.S., Garlanda C., Mantovani A., Torzilli G., Mikulak J.#, Mavilio D.#* Intrahepatic CD69+Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression. Journal for Immunotherapy of Cancer, 2022 Jul;10(7):e004579.

Di Vito C.*#, Calcaterra F.#, Coianiz N., Terzoli S., Voza A., Mikulak J.#, Della Bella S.#, Mavilio D.#* Natural Killer Cells in SARS-CoV-2 Infection: Pathophysiology and Therapeutic Implications. Frontiers in Immunology, 2022 Jun 30;13:888248.

Calvi M., Di Vito C., Frigo A., Trabanelli S., Jandus C., Mavilio D.* Development of Human ILCs and Impact of Unconventional Cytotoxic Subsets in the Pathophysiology of Inflammatory Diseases and Cancer. Frontiers in Immunology, 2022 May 26;13:914266.

Cazzetta V., Elena Bruni E., Terzoli S., Carenza C., Franzese S., Piazza R., Donadon M., Torzilli G., Cimino M., Simonelli M., Bello L., Villa A., Tan L., Ravens S., Prinz I., Supino D., Colombo F.S., Lugli E., Marcenaro E., Vivier E., Della Bella S., Mikulak J.#, Mavilio D.#* NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions. Cell Reports, 2021 Oct 19;37(3):109871.

Van Beek J.P., Puccio S., Roberto A., De Paoli F., Graziano G., Salviato E., Alvisi G., Zanon V., Scarpa A., Zaghi E., Calvi M., Di Vito C., Mineri R., Sarina B., De Philippis C., Santoro A., Mariotti J., Bramanti S., Ferrari F., Castagna L., Mavilio D. and Lugli E. Single-cell profiling reveals the dynamics of cytomegalovirusspecific T cells in haploidentical hematopoietic stem cell transplantation. Haematologica, 2021 Oct 1;106(10):2768-2773.

Zaghi E., Calvi M., Puccio S., Spata G., Terzoli S., Peano C., Roberto A., De Paoli F., van Beek J., Mariotti J., De Philippis C., Sarina B., Mineri R., Bramanti S., Santoro A., Khanh Le-Trilling V.T., Trilling M, Marcenaro E., Castagna L., Di Vito C.#*, Lugli E. and Mavilio D.#* Single-cell profiling identifies impaired adaptive NK cells expanded after HCMV reactivation in haploidentical-HSCT. JCI Insight, 2021 May 18:146973.

Cazzetta V.#, Franzese S.#, Carenza C., Della Bella S., Mikulak and Mavilio D.* Natural Killer–Dendritic Cell Interactions in Liver Cancer: Implications for Immunotherapy. Cancers, 2021 May 1;13(9):2184.

Mariotti J., Raiola A.M., Evangelista A., Carella A.M., Martino M., Patriarca F., Risitano A., Bramanti S., Busca A., Giaccone L., Brunello L.., Merla E., Savino L., Lotetra B., Console G., Fanin R., Sperotto A., Marano L., Marotta S., Frieri C., Sica S., Chiusolo P., Harbi S., Furst S., Santoro A., Bacigalupo A., Blaise B., Angelucci E., Mavilio D.#, Castagna L.#* and Bruno B.# Impact of Donor Age and Kinship on Clinical Outcomes after T Cell-replete Haploidentical Transplantation with Post-transplant Cyclophosphamide. Blood Advances, 2020 4(16): 3900–3912.

Della Bella S. #*, Calcaterra F.#, Bacci M., Carenza C., Pandolfo C., Ferrazzi P., Uva P., Pagani M., Lodigiani C.# and Mavilio D.#* Pathologic up-regulation of TNFSF15-TNFRSF25 axis sustains endothelial dysfunction in unprovoked venous thromboembolism. Cardiovascular Research, 2020 Mar 1;116(3):698-707.

Mikulak J., Di Vito C., Mavilio D.* HIV-1-induced inflammation shapes innate immunity and induces adaptive traits for NK cells. Nature Immunology, 2020 Mar;21(3):245-247.

Mikulak J.#, Oriolo F.#, Bruni E., Roberto A., Colombo F.S., Villa A., Bosticardo M., Bortolomai I., Lo Presti E., Meraviglia S., Dieli F., Vetrano S., Danese S., Della Bella S., Carvello M.M., Sacchi M., Cugini G., Colombo G., Klinger M., Spaggiari P., Roncalli M., Prinz I., Ravens S., Di Lorenzo B., Marcenaro E., Silva-Santos B., Spinelli A. and Mavilio D.* NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer. JCI Insight, 2019 Dec 19;4(24).

Bruni E., Cazzetta V., Donadon M., Cimino M., Torzilli G., Spata G., Leonardi G., Dieli F., Mikulak J.* and Mavilio D.* Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. Journal for Immunotherapy of Cancer, 2019 Dec 11;7(1):347.

Roberto A., Di Vito C., Zaghi E., Mazza E.M.C., Capucetti A., Calvi M., Tentorio P., Zanon V., Sarina B., Mariotti J., Bramanti S., Tenedini E., Tagliafico E., Bicciato S., Santoro A., Roederer M., Marcenaro E., Castagna L., Lugli E.#* and Mavilio D.#* The early expansion of anergic NKG2Apos/CD56dim/CD16neg natural killer represents a therapeutic target in haploidentical haematopoietic stem cell transplantation. Haematologica, 2018 Aug;103(8):1390-1402.

Calcaterra F., Brambilla L., Colombo E., Tourlaki A., Veraldi S., Carenza C., Mavilio D.# and Della Bella S.#* Increased frequency and vasculogenic potential of endothelial colony-forming cells in patients with Kaposi’s sarcoma. Journal of Investigative Dermatology, 2017 Jul;137(7):1533-1540.

Donadon M., Hudspeth K, Cimino M., Di Tommaso L., Preti M., Tentorio P., Roncalli M., Mavilio D.#* and Torzilli G.# Increased infiltration of Natural Killer and T cells in colorectal liver metastases improves patient overall survival. Journal of Gastrointestinal Surgery, 2017 Aug;21(8):1226-1236.

Hudspeth K., Donadon M., Cimino M., Pontarini E., Tentorio P., Preti M., Hong M., Bertoletti A., Bicciato S., Invernizzi P., Lugli E., Torzilli G., Gershwin M.E.*, Mavilio D.* Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways. Journal of Autoimmunity, 2016 Jan;66:40-50.

Mikulak J*, Oriolo F., Portale F., Tentorio P., Lan X., Saleem M.A., Skorecki K., Singhal P.C. and Mavilio D.* Impact of APOL1 polymorphism and IL-1 priming in the entry and persistence of HIV-1 in human podocytes. Retrovirology, 2016 Sept. 6,13(63).

Cappelletti M., Presicce P., Calcaterra F., Mavilio D.# and Della Bella S.# Bright expression of CD91 identifies highly activated human dendritic cells that can be expanded by defensins. Immunology, 2015 Apr;144(4):661-7.

Roberto A., Castagna L., Gandolfi S., Zanon V., Bramanti S., Sarina B., Crocchiolo R., Todisco E., Carlo- Stella C., Tentorio P., Timofeeva I., Santoro A., Della Bella S., Roederer M., Mavilio D.#* and Lugli E.#* B cell reconstitution after unmanipulated haploidentical bone marrow transplantation recapitulates B-cell lymphopoiesis. Bone Marrow Transplantation, 2015 Feb;50(2):317-9.

Roberto A., Castagna L., Zanon V., Bramanti S., Crocchiolo R., McLaren J.E., Gandolfi S., Tentorio P., Sarina B., Timofeeva I., Santoro A., Carlo-Stella C., Bruno B., Carniti C., Corradini P., Gostick E., Ladell K., Price D.A., Roederer M., Mavilio D.#* and Lugli E.#* Role of naïve-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood, 2015 Apr 30;125(18):2855-64.

Hudspeth K., Fogli M., Correia D.V., Mikulak J., Roberto A., Della Bella S., Silva-Santos B.# and Mavilio D.#* Engagement of NKp30 on Vd1 T-cells induces the production of CCL3, CCL4 and CCL5 and suppresses HIV-1 replication. Blood, 2012 Apr 26;119(17):4013-6.

Correia D.V., Fogli M., Hudspeth K.L. Da Silva, M.G., Mavilio D.# and Silva-Santos B.#* Differentiation of human peripheral blood Vδ1+ T-cells expressing the Natural Cytotoxicity Receptor NKp30 for recognition of lymphoid leukemia cells. Blood, 2011 Jul 28;118(4):992-1001.