Selected Publications: 20-25 publications listed in details with all the contributing authors, title of the papers, journal, dates.

Hirsch E., Katanaev V. L., Garlanda C., Azzolino O., Pirola L., Silengo L., Sozzani S., Mantovani A., Altruda F. and Wymann M. P. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 287: 5455, 1049-53, 2000. https://www.ncbi.nlm.nih.gov/pubmed/10669418.

 

Garlanda C., Hirsch E., Bozza S., Salustri A., De Acetis M., Nota R., Maccagno A., Riva F., Bottazzi B., Peri G., Doni A., Vago L., Botto M., De Santis R., Carminati P., Siracusa G., Altruda F., Vecchi A., Romani L. and Mantovani A. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 420: 182-186, 2002.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12432394

 

Garlanda C., Riva F., Polentarutti N., Buracchi C., Sironi M., De Bortoli M., Muzio M., Bergottini R., Scanziani E., Vecchi A., Hirsch E. and Mantovani A. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci U S A. 101: 10, 3522-6, 2004. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14993616.

 

Garlanda C., Bottazzi B., Bastone A. and Mantovani A. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol. 23: 337-66, 2005. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15771574

 

Jaillon S., Peri G., Delneste Y., Fremaux I., Doni A., Moalli F., Garlanda C., Romani L., Gascan H., Bellocchio S., Bozza S., Cassatella M. A., Jeannin P. and Mantovani A. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med. 204: 4, 793-804, 2007. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17389238

 

Bottazzi B., Doni A., Garlanda C. and Mantovani A. An integrated view of humoral innate immunity: pentraxins as a paradigm. Annu Rev Immunol. 28: 157-83, 2010. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19968561

 

Moalli F., Doni A., Deban L., Zelante T., Zagarella S., Bottazzi B., Romani L., Mantovani A. and Garlanda C. Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood. 116: 24, 5170-80, 2010. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20829368

 

Moalli F., Paroni M., Veliz Rodriguez T., Riva F., Polentarutti N., Bottazzi B., Valentino S., Mantero S., Nebuloni M., Mantovani A., Bragonzi A. and Garlanda C. The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol. 186: 9, 5425-34, 2011. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21441447

 

Mantovani A., Cassatella MA., Costantini C and Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 11(8):519-31, 2011. https://www.ncbi.nlm.nih.gov/pubmed/21785456

 

Garlanda C., Dinarello C. A. and Mantovani A. The interleukin-1 family: back to the future. Immunity. 39: 6, 1003-18, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24332029.

 

Jaillon S., Moalli F., Ragnarsdottir B., Bonavita E., Puthia M., Riva F., Barbati E., Nebuloni M., Cvetko Krajinovic L., Markotic A., Valentino S., Doni A., Tartari S., Graziani G., Montanelli A., Delneste Y., Svanborg C., Garlanda C. and Mantovani A. The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection. Immunity. 40: 4, 621-32, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24745336.

 

Jaillon S., Mancuso G., Hamon Y., Beauvillain C., Cotici V., Midiri A., Bottazzi B., Nebuloni M., Garlanda C., Fremaux I., Gauchat JF., Descamps P., Beninati C., Mantovani A., Jeannin P and Delneste Y. Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from pseudomonas aeruginosa lung infection. J Immunol. 191(4):1873-82, 2013. https://www.ncbi.nlm.nih.gov/pubmed/23863905

 

Bonavita E., Gentile S., Rubino M., Maina V., Papait R., Kunderfranco P., Greco C., Feruglio F., Molgora M., Laface I., Tartari S., Doni A., Pasqualini F., Barbati E., Basso G., Galdiero M. R., Nebuloni M., Roncalli M., Colombo P., Laghi L., Lambris J. D., Jaillon S., Garlanda C. and Mantovani A. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. 160: 4, 700-14, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25679762.

 

Nold-Petry C. A., Lo C. Y., Rudloff I., Elgass K. D., Li S., Gantier M. P., Lotz-Havla A. S., Gersting S. W., Cho S. X., Lao J. C., Ellisdon A. M., Rotter B., Azam T., Mangan N. E., Rossello F. J., Whisstock J. C., Bufler P., Garlanda C., Mantovani A., Dinarello C. A. and Nold M. F. IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol. 16: 4, 354-65, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25729923.

 

Doni A., Musso T., Morone D., Bastone A., Zambelli V., Sironi M., Castagnoli C., Cambieri I., Stravalaci M., Pasqualini F., Laface I., Valentino S., Tartari S., Ponzetta A., Maina V., Barbieri S. S., Tremoli E., Catapano A. L., Norata G. D., Bottazzi B., Garlanda C. and Mantovani A. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 212: 6, 905-25, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25964372.

 

Galdiero MR., Bianchi P., Grizzi F., Di Caro G., Basso G., Ponzetta A., Bonavita E., Barbagallo M., Tartari S., Polentarutti N., Malesci A., Marone G., Roncalli M., Laghi L., Garlanda C., Mantovani A and Jaillon S. Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer. Int J Cancer. 139(2):446-56, 2016.

https://www.ncbi.nlm.nih.gov/pubmed/28471269

 

Garlanda C., Jaillon S., Doni A., Bottazzi B and Mantovani A. PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition. Curr Opin Immunol. 38:39-44, 2016. https://www.ncbi.nlm.nih.gov/pubmed/26650391

 

Rubino M., Kunderfranco P., Basso G., Greco C. M., Pasqualini F., Serio S., Roncalli M., Laghi L., Mantovani A., Papait R. and Garlanda C. Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer. Oncoimmunology. 6: 7, e1333215, 2017. https://www.ncbi.nlm.nih.gov/pubmed/28811977.

 

Molgora M., Bonavita E., Ponzetta A., Riva F., Barbagallo M., Jaillon S., Popovic B., Bernardini G., Magrini E., Gianni F., Zelenay S., Jonjic S., Santoni A., Garlanda C. and Mantovani A. IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity. Nature. 551: 7678, 110-114, 2017. https://www.ncbi.nlm.nih.gov/pubmed/29072292.

 

Garlanda C., Bottazzi B., Magrini E., Inforzato A. and Mantovani A. PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer. Physiol Rev. 98: 2, 623-639, 2018. https://www.ncbi.nlm.nih.gov/pubmed/29412047.

 

Riva F., Ponzoni M., Supino D., Bertilaccio M. T. S., Polentarutti N., Massara M., Pasqualini F., Carriero R., Innocenzi A., Anselmo A., Veliz-Rodriguez T., Simonetti G., Anders H. J., Caligaris-Cappio F., Mantovani A., Muzio M. and Garlanda C. IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development. Cancer Immunol Res. 7: 6, 874-885, 2019. https://www.ncbi.nlm.nih.gov/pubmed/31018956.

 

Mantovani A., Dinarello C. A., Molgora M. and Garlanda C. Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity. 50: 4, 778-795, 2019.https://www.ncbi.nlm.nih.gov/pubmed/30995499.

 

Ponzetta A., Carriero R., Carnevale S., Barbagallo M., Molgora M., Perucchini C., Magrini E., Gianni F., Kunderfranco P., Polentarutti N., Pasqualini F., Di Marco S., Supino D., Peano C., Cananzi F., Colombo P., Pilotti S., Alomar S. Y., Bonavita E., Galdiero M. R., Garlanda C., Mantovani A. and Jaillon S. Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors. Cell. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31257026.