Selected Publications: 20-25 publications listed in details with all the contributing authors, title of the papers, journal, dates.

Garassino MC, Torri V, Colombo MP, Sica A. Choosing the Best Chemotherapy Agent to Boost Immune Checkpoint Inhibition Activity. Cancer Res. 2018 Oct 15;78(20):5729-5730. PMID: 30322956

 

Porta C, Ippolito A, Consonni FM, Carraro L, Celesti G, Correale C, Grizzi F, Pasqualini F, Tartari S, Rinaldi M, Bianchi P, Balzac F, Vetrano S, Turco E, Hirsch E, Laghi L, Sica A. Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression. Cancer Immunol Res. 2018 May;6(5):578-593. PMID: 29588321

 

Sica A, Strauss L. Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology. J Leukoc Biol. 2017 Aug;102(2):325-334. PMID: 28223316

 

Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, Mandruzzato S, Murray PJ, Ochoa A, Ostrand-Rosenberg S, Rodriguez PC, Sica A, Umansky V, Vonderheide RH, Gabrilovich DI. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 2016 Jul 6;7:12150. PMID: 27381735

 

Strauss L, Sangaletti S, Consonni FM, Szebeni G, Morlacchi S, Totaro MG, Porta C, Anselmo A, Tartari S, Doni A, Zitelli F, Tripodo C, Colombo MP, Sica A. RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis. Cancer Cell, 2015, 28(2):253-69. Feature Article. PMID: 26267538

 

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity, 2014, 41(1):14-20. PMID: 25035950

 

Ries CH, Cannarile MA, Hoves S, Benz J, Wartha K, Runza V, Rey-Giraud F, Pradel LP, Feuerhake F, Klaman I, Jones T, Jucknischke U, Scheiblich S, Kaluza K, Gorr IH, Walz A, Abiraj K, Cassier PA, Sica A, Gomez-Roca C, de Visser KE, Italiano A, Le Tourneau C, Delord JP, Levitsky H, Blay JY, Rüttinger D. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell, 2014, 25(6):846-59. PMID: 24898549

 

Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas . J. Clin Invest., 2012, 122(3):787-95. PMID: 22378047

 

Porta C, Rimoldi M, Raes G, Brys L, Ghezzi P, Di Liberto D, Dieli F, Ghisletti S, Natoli G, De Baetselier P, Mantovani A, Sica A. Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor-B. Proc Natl Acad Sci U S A, 2009; 106:14978-14983. PMID: 19706447

 

  1. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related Inflammation. Nature, 2008, 454:436-444. PMID: 18650914

 

 

Mancino A, Schioppa T, Larghi P, Pasqualini P, Nebuloni M, Chen I-Hsuan, Sozzani S, Austyn JM, Mantovani A, Sica A. Divergent Effects of Hypoxia on Dendritic Cell Functions. Blood, 2008, 112:3723-3734. PMID: 18694997

 

Sica A, Bronte V. Altered macrophage differentiation and immune dysfunctions during tumor development. J. Clin Invest, 2007, 117:1155-1166. PMID: 17476345

 

Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Bronte V, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A. A distinct and unique transcriptional programme expressed by tumor-associated macrophages: defective NF-{kappa}B and enhanced IRF-3/STAT1 activation. Blood, 2006, 107:2112-2122. PMID: 16269622

 

Saccani A, Schioppa T, Porta C, Biswas SK, Nebuloni M, Vago L, Bottazzi B, Colombo MP, Mantovani A, Sica A. p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. Cancer Research, 2006, 66:11432-11440. PMID: 17145890

 

Larghi P, Porta C, Riboldi E, Totaro MG, Carraro L, Orabona C, Sica A.The p50 subunit of NF-κB orchestrates dendritic cell lifespan and activation of adaptive immunity. PLoS One. 2012;7(9):e45279. PMID: 23049782

 

Schioppa T, Uranchimeg B, Saccani A, Biswas SK, Doni A, Rapisarda A, Bernasconi S, Saccani S, Nebuloni M, Vago L, Mantovani A, Melillo G, Sica A. Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med. 2003 Nov 3;198(9):1391-402. PMID: 14597738

 

Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002 Nov;23(11):549-55. PMID: 12401408

 

Saccani A, Saccani S, Orlando S, Sironi M, Bernasconi S, Ghezzi P, Mantovani A, Sica A. Redox regulation of chemokine receptor expression. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2761-6. PMID: 10716998

 

Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A. Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages. J Immunol. 2000 Jan 15;164(2):762-7. PMID: 10623821

 

Sica A, Saccani A, Bottazzi B, Bernasconi S, Allavena P, Gaetano B, Fei F, LaRosa G, Scotton C, Balkwill F, Mantovani A. Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol. 2000 Jan 15;164(2):733-8. PMID:10623817