Cytoskeleton protein Filamin A is required for efficient Somatostatin receptor type 2 internalization and recycling
through Rab5 and Rab4 sorting endosomes in tumor somatotroph cells. Treppiedi D, Mangili F, Giardino E, Catalano R, Locatelli M, Lania A, Spada A, Arosio M, Calebiro D, Mantovani G, Peverelli E. Neuroendocrinology. 2019 Oct 1. doi: 10.1159/000503791. PubMed PMID: 31574507
cAMP/PKA-induced filamin A (FLNA) phosphorylation inhibits SST2 signal transduction in GH-secreting pituitary tumor cells. Peverelli E, Giardino E, Mangili F, Treppiedi D, Catalano R, Ferrante E, Sala E, Locatelli M, Lania AG, Arosio M, Spada A, Mantovani G. Cancer Lett. 2018 Oct 28;435:101-109. doi: 10.1016/j.canlet.2018.08.002. Epub 2018 Aug 8. PMID: 30098401
A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment. Peverelli E, Giardino E, Treppiedi D, Catalano R, Mangili F, Locatelli M, Lania AG, Arosio M, Spada A, Mantovani G. Int J Cancer. 2018 May 1;142(9):1842-1852. doi: 10.1002/ijc.31205. Epub 2017 Dec 20. PMID:29226331
FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression. Vitali E, Boemi I, Rosso L, Cambiaghi V, Novellis P, Mantovani G, Spada A, Alloisio M, Veronesi G, Ferrero S, Lania AG. Oncotarget. 2017 Aug 24;8(44):77330-77340. doi: 10.18632/oncotarget.20473. eCollection 2017 Sep 29. PMID: 29100390
Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors. Peverelli E, Giardino E, Treppiedi D, Meregalli M, Belicchi M, Vaira V, Corbetta S, Verdelli C, Verrua E, Serban AL, Locatelli M, Carrabba G, Gaudenzi G, Malchiodi E, Cassinelli L, Lania AG, Ferrero S, Bosari S, Vitale G, Torrente Y, Spada A, Mantovani G. Int J Cancer. 2017 Apr 15;140(8):1870-1880. doi: 10.1002/ijc.30613. Epub 2017 Feb 8. PMID:28120505.
Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation. Peverelli E, Giardino E, Treppiedi D, Locatelli M, Vaira V, Ferrero S, Bosari S, Lania AG, Spada A, Mantovani G. Cancer Lett. 2016 Oct 28;381(2):279-86. doi: 10.1016/j.canlet.2016.08.005. Epub 2016 Aug 9. PMID: 27519461
Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line. Cambiaghi V, Vitali E, Morone D, Peverelli E, Spada A, Mantovani G, Lania AG. Endocrine. 2017 Apr;56(1):146-157. doi: 10.1007/s12020-016-1026-2. Epub 2016 Jul 12. PMID: 27406390
Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours. Vitali E, Cambiaghi V, Zerbi A, Carnaghi C, Colombo P, Peverelli E, Spada A, Mantovani G, Lania AG. Endocr Relat Cancer. 2016 Mar;23(3):181-90. doi: 10.1530/ERC-15-0358. Epub 2016 Jan 5. PMID: 26733502
cAMP effects in neuroendocrine tumors: The role of Epac and PKA in cell proliferation and adhesion. Vitali E, Cambiaghi V, Spada A, Tresoldi A, Zerbi A, Peverelli E, Carnaghi C, Mantovani G, Lania AG. Exp Cell Res. 2015 Dec 10;339(2):241-51. doi: 10.1016/j.yexcr.2015.11.011. Epub 2015 Nov 14.PMID: 26589262
Different expression of protein kinase A (PKA) regulatory subunits in normal and neoplastic thyroid tissues. Ferrero S, Vaira V, Del Gobbo A, Vicentini L, Bosari S, Beck-Peccoz P, Mantovani G, Spada A, Lania AG. Histol Histopathol. 2015 Apr;30(4):473-8. doi: 10.14670/HH-30.473. Epub 2014 Sep 26. PMID: 25393625
Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells. Peverelli E, Giardino E, Treppiedi D, Vitali E, Cambiaghi V, Locatelli M, Lasio GB, Spada A, Lania AG, Mantovani G. Endocrinology. 2014 Aug;155(8):2932-41. doi: 10.1210/en.2014-1063. Epub 2014 May 14. PMID: 24828612
Filamin-A is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs. Peverelli E, Mantovani G, Vitali E, Elli FM, Olgiati L, Ferrero S, Laws ER, Della Mina P, Villa A, Beck-Peccoz P, Spada A, Lania AG. J Clin Endocrinol Metab. 2012 Mar;97(3):967-77. doi: 10.1210/jc.2011-2902. Epub 2012 Jan 18. PMID: 22259062
Influence of the d3GH receptor polymorphism on the metabolic and biochemical phenotype of GH-deficient adults at baseline and during short- and long-term recombinant human GH replacement therapy. Giavoli C, Ferrante E, Profka E, Olgiati L, Bergamaschi S, Ronchi CL, Verrua E, Filopanti M, Passeri E, Montefusco L, Lania AG, Corbetta S, Arosio M, Ambrosi B, Spada A, Beck-Peccoz P. Eur J Endocrinol. 2010 Sep;163(3):361-8. doi: 10.1530/EJE-10-0317. Epub 2010 Jun 30. PMID: 20592127
d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype.Montefusco L, Filopanti M, Ronchi CL, Olgiati L, La-Porta C, Losa M, Epaminonda P, Coletti F, Beck-Peccoz P, Spada A, Lania AG, Arosio M. Clin Endocrinol (Oxf). 2010 May;72(5):661-7. doi: 10.1111/j.1365-2265.2009.03703.x. PMID:20447065
Role of UGT1A1 and ADH gene polymorphisms in pegvisomant-induced liver toxicity in acromegalic patients. Filopanti M, Barbieri AM, Mantovani G, Corbetta S, Gasco V, Ragonese M, Martini C, Bogazzi F, Colao A, Ferone D, Peri A, Pigliaru F, Angeletti G, Arosio M, Beck-Peccoz P, Lania AG, Spada A. Eur J Endocrinol. 2013 Dec 21;170(2):247-54. doi: 10.1530/EJE-13-0657. Print 2014 Feb. PMID: 24217933
The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways.Peverelli E, Olgiati L, Locatelli M, Magni P, Fustini MF, Frank G, Mantovani G, Beck-Peccoz P, Spada A, Lania A.Cancer Lett. 2010 Feb 28;288(2):170-6. doi: 10.1016/j.canlet.2009.06.034. Epub 2009 Jul 19. PMID: 19619936
Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients. Peverelli E, Ermetici F, Filopanti M, Elli FM, Ronchi CL, Mantovani G, Ferrero S, Bosari S, Beck-Peccoz P, Lania A, Spada A. Eur J Endocrinol. 2009 Nov;161(5):687-94. doi: 10.153 0/EJE-09-0677. Epub 2009 Aug 11. PMID:
Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cells. Bondioni S, Angioni AR, Corbetta S, Locatelli M, Ferrero S, Ferrante E, Mantovani G, Olgiati L, Beck-Peccoz P, Spada A, Lania AG. Exp Biol Med (Maywood). 2008 Apr;233(4):439-46. doi: 10.3181/0704-RM-94. PMID: 18367633
Dopamine D2 receptor gene polymorphisms and response to cabergoline therapy in patients with prolactin-secreting pituitary adenomas. Filopanti M, Barbieri AM, Angioni AR, Colao A, Gasco V, Grottoli S, Peri A, Baglioni S, Fustini MF, Pigliaru F, Monte PD, Borretta G, Ambrosi B, Jaffrain-Rea ML, Gasperi M, Brogioni S, Cannavò S, Mantovani G, Beck-Peccoz P, Lania A, Spada A. Pharmacogenomics J. 2008 Oct;8(5):357-63. doi: 10.1038/tpj.2008.1. Epub 2008 Mar 11. PMID: 18332900
Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein. Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A. Cancer Res. 2004 Dec 15;64(24):9193-8.PMID:15604292
Effect of cyclic adenosine 3′,5′-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas. Mantovani G, Bondioni S, Ferrero S, Gamba B, Ferrante E, Peverelli E, Corbetta S, Locatelli M, Rampini P, Beck-Peccoz P, Spada A, Lania AG. J Clin Endocrinol Metab. 2005 Dec;90(12):6721-4. Epub 2005 Oct 4.PMID: 16204369.
High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells. Mantovani G, Bondioni S, Lania AG, Rodolfo M, Peverelli E, Polentarutti N, Veliz Rodriguez T, Ferrero S, Bosari S, Beck-Peccoz P, Spada A. Oncogene. 2008 Mar 20;27(13):1834-43. Epub 2007 Oct 1. PMID: 17906691