The Orbitrap Exploris 120 delivers sub-ppm mass accuracy, enabling accurate, selective detection of target analytes over five orders of linear quantitative dynamic range without detector saturation. Resolve ions of interest from interfering ions with high mass resolution up to 120,000 (FWHM) at m/z 200 over the mass range m/z 40–3,000. It allows different scanning modalities such as Full scan, MRM and DIA relying on hybrid Quadrupole-Orbitrap technology. It is used for targeted and semi-targeted metabolomics, targeted and semi-targeted imaging mass spectrometry and pharmacokinetics analysis.