Leonardo Elia Junior PI Vascular Epigenetics View More
Our group aims at understanding the involvement of epigenetics in the development of vascular diseases. Thus, we mainly focus on the identification of new molecular pathways regulating vascular smooth muscle and endothelial cell biology, and in which DNA methylation, histone modifications, and non-coding RNAs expression play a major role. In order to achieve these goals, we employ methodologies such as DNA/RNA sequencing, single-cell analysis (10x Genomics), molecular and cellular biology, high-end molecular imaging and in vivo models of vascular diseases. The relevance of our bench findings is then further investigated in translational studies.
The ultimate scope is to find innovative approaches to treat vascular pathologies.
Main macro-areas of interest:
Epigenetics and vascular diseases.
To understand how pathological stimuli alter gene expression through chromatin remodeling and how such mechanisms are involved in vascular disease development.
Non-coding RNAs in vascular cell biology.
miRNAs and long non-coding RNAs are fundamental players regulating vascular smooth muscle and endothelial cells phenotype, thus we aim to identify how they interact in such process.
Leonardo Elia Publications
Selected Publications: 20-25 publications listed in details with all the contributing authors, title of the papers, journal, dates. Stratton MS, Farina FM, Elia L#. “Epigenetics and vascular diseases.” Journal of Molecular and Cellular ...