Marrella V, Facoetti A, Cassani B. Cellular Senescence in Immunity against Infections. Int J Mol Sci. 2022 Oct; 23(19): 11845.
Farini A, Tripodi L, Villa C, Strati F, Facoetti A, Baselli G, Troisi J, Landolfi A, Lonati C, Molinaro D, Wintzinger M, Gatti S, Cassani B, Caprioli F, Facciotti F, Quattrocelli M, Torrente Y. Microbiota Dysbiosis Influences Immune System and Muscle Pathophysiology of Dystrophin Deficient Mice. EMBO Mol Med (2022)e16244.
Farini, C. Sitzia, C. Villa, B. Cassani, L. Tripodi, M. Legato, M. Belicchi, P. Bella, C. Lonati, S. Gatti, M. Cerletti, Y. Torrente. Defective dystrophic thymus determines degenerative changes in skeletal muscle. Nat Commun. 2021; 12: 2099. doi: 10.1038/s41467-021-22305-x
Rigoni R, Fontana E, Dobbs K, Marrella V, Taverniti V, Maina V, Facoetti A, D’Amico G, Al-Herz W, Cruz-Munoz ME, Schuetz C, Gennery AR, Garabedian EK, Giliani S, Draper D, Dbaibo G, Geha RS, Meyts I, Tousseyn T, Neven B, Moshous D, Fischer A, Schulz A, Finocchi A, Kuhns DB, Fink DL, Lionakis MS, Swamydas M, Guglielmetti S, Alejo J, Myles IA, Pittaluga S, Notarangelo LD, Villa A, Cassani B. Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome. J Allergy Clin Immunol. 2020 Apr 18:S0091-6749(20)30492-9. DOI: 10.1016/j.jaci.2020.04.005
Menale C, Robinson LJ, Palagano E, Rigoni R, Erreni M, Almarza AJ, Strina D, Mantero S, Lizier M, Forlino A, Besio R, Monari M, Vezzoni P, Cassani B, Blair HC, Villa A, Sobacchi C. Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss. J Bone Miner Res. 2019 Nov;34(11):2133-2148. doi: 10.1002/jbmr.3829.
Pellicciotta M, Rigoni R, Falcone EL, Holland SM, Villa A, Cassani B. The microbiome and immunodeficiencies: Lessons from rare diseases. J Autoimmun. 2019 Jan 28. pii: S0896 -8411(18)30649-8. DOI: 10.1016/j.jaut.2019.01.008. Invited Review
Capo V, Castiello MC, Fontana E, Penna S, Bosticardo M, Draghici E, Poliani LP, Sergi LS, Rigoni R, Cassani B, Zanussi M, Carrera P, Uva P, Dobbs K, Sacchetti N, Notarangelo LD, van Til NP, Wagemaker G, Villa A. Efficacy of lentiviral mediated gene therapy in an Omenn syndrome Rag2 mouse model is not hindered by inflammation and immune dysregulation. J Allergy Clin Immunol. 2018 Sep;142(3):928-941.e8. DOI: 10.1016/j.jaci.2017.11.015.
Faggioli F, Palagano E, Di Tommaso L, Donadon M, Marrella V, Recordati C, Mantero S, Villa A, Vezzoni P, Cassani B. B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury. Hepatology. 2018 May;67(5):1970-1985. DOI: 10.1002/hep.29636.
Rigoni, E. Fontana, S. Guglielmetti, B. Fosso, A.M. D’Erchia, V. Maina, V. Taverniti, M.C. Castiello, S. Mantero, G. Pacchiana, S. Musio, R. Pedotti, J.R. Mora, G. Pesole, P. Vezzoni, P.L. Poliani, F. Grassi, A. Villa and B. Cassani. Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects. 2016 J Exp Med. 213(3):355-75. DOI: 10.1084/jem.20151116
Pala F, Morbach H, Castiello MC, Schickel JN, Scaramuzza S, Chamberlain N, Cassani B, Glauzy S, Romberg N, Candotti F, Aiuti A, Bosticardo M, Villa A, Meffre E. Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. 2015 J Clin Invest. 125(10):3941-51. DOI: 10.1172/JCI82249
Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. Gut-Tropic T Cells That Express Integrin α4β7 and CCR9 Are Required for Induction of Oral Immune Tolerance in Mice. 2011 Gastroenterology. 141(6):2109-18. DOI: 10.1053/j.gastro.2011.09.015
Villablanca*, B. Cassani*, UH. von Andrian and JR. Mora. Blocking Lymphocyte Localization to the Gastrointestinal Mucosa as a Therapeutic Strategy for Inflammatory Bowel Diseases. 2011 Gastroenterology 140(6):1776-84. DOI: 10.1053/j.gastro.2011.02.015
Cassani B, Poliani PL, Marrella V, Schena F, Sauer AV, Ravanini M, Strina D, Busse CE, Regenass S, Wardemann H, Martini A, Facchetti F, van der Burg M, Rolink AG, Vezzoni P, Grassi F, Traggiai E, Villa A. Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome. 2010 J Exp Med. 207(7):1525-40. DOI: 10.1084/jem.20091928
Cassani B, Montini E, Maruggi G, Ambrosi A, Mirolo M, Selleri S, Biral E, Frugnoli I, Hernandez-Trujillo V, Di Serio C, Roncarolo MG, Naldini L, Mavilio F, Aiuti A. Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy. 2009 Blood. 114(17):3546-56. DOI: 10.1182/blood-2009-02-202085
Aiuti A, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L, Scaramuzza S, Andolfi G, Mirolo M, Brigida I, Tabucchi A, Carlucci F, Eibl M, Aker M, Slavin S, Al-Mousa H, Al Ghonaium A, Ferster A, Duppenthaler A, Notarangelo L, Wintergerst U, Buckley RH, Bregni M, Marktel S, Valsecchi MG, Rossi P, Ciceri F, Miniero R, Bordignon C, Roncarolo MG. Gene therapy for immunodeficiency due to adenosine deaminase deficiency. 2009 N Engl J Med. 360(5):447-58. DOI: 10.1056/NEJMoa0805817
Guerrini MM, Sobacchi C, Cassani B, Abinun M, Kilic SS, Pangrazio A, Moratto D, Mazzolari E, Clayton-Smith J, Orchard P, Coxon FP, Helfrich MH, Crockett JC, Mellis D, Vellodi A, Tezcan I, Notarangelo LD, Rogers MJ, Vezzoni P, Villa A, Frattini A. Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations. 2008 Am J Hum Genet. 83(1):64-76. DOI: 10.1016/j.ajhg.2008.06.015
Cassani B, Mirolo M, Cattaneo F, Benninghoff U, Hershfield M, Carlucci F, Tabucchi A, Bordignon C, Roncarolo MG, Aiuti A. Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. 2008 Blood. 111(8):4209-19. DOI: 10.1182/blood-2007-05-092429
Aiuti A, Cassani B, Andolfi G, Mirolo M, Biasco L, Recchia A, Urbinati F, Valacca C, Scaramuzza S, Aker M, Slavin S, Cazzola M, Sartori D, Ambrosi A, Di Serio C, Roncarolo MG, Mavilio F, Bordignon C. Multilineage hematopoietic reconstitution without clonal selection in ADASCID patients treated with stem cell gene therapy. 2007 J Clin Invest. 117(8):2233-40. DOI: 10.1172/JCI31666