Michela Matteoli

Michela Matteoli, PhD


Role: Director of Neurological Research Area and Head of Lab
Unit: Pharmacology and Brain Pathology Lab
Hospital: Humanitas Clinical and Research Center, Italy

Role: Full Professor of Pharmacology
University: Humanitas University, Italy



Biographical note

Michela Matteoli received her PhD from the University of Pisa in 1989. From 1989 to 1991 she has been postdoctoral fellow at the Yale University School of Medicine and Visiting Scientist at the Virginia School of Medicine. In 1992 she established her laboratory at the CNR-Center of Molecular and Cellular Pharmacology. In 2002 she became Associate Professor of Pharmacology at the University of Milano. Since 2011 is Full Professor. Since 2013 she is Head of the Neuroscience Program at Humanitas, Clinical and Research Center and since 2014 she is Director of the CNR Italian Institute of Neuroscience.
Michela Matteoli has been awarded with EMBO and IBRO-MacArthur fellowships. In 2013 she received the Mid-Career Nature Mentoring Award and in 2015 the Atena prize for scientific achievements. Member of the European Molecular Biology Organization (EMBO) and the Academia Europaea due to outstanding scientific achievements. She is part of the international scientific advisory boards of the Paris School of Neuroscience, the Armenise Harvard Foundation, the Center of Psychiatry and Neurosciences of INSERM and Paris-Descartes University, Fondazione Veronesi and Fondazione Volta. She has been coordinator or partner in several scientific networks, including NATO, HFSP and EC-FP7. Her scientific activity is also funded by Telethon, Cariplo, Italian Ministry of Health, Italian Ministry of Education University and Research.
Michela Matteoli is in the Editorial Board of many scientific journals and acts as ad hoc reviewer for several international journals including Science, Nature, PNAS, EMBO Journal, Neuron, TINS, Journal of Cell Biology, Journal of Neuroscience.
Michela  Matteoli has authored over 120 research papers and scientific reviews with an average Impact Factor of around 7 and several book chapters. Her H index is 50 (top Italian scientists).

Scientific interests

Synapses are fundamental brain structures that mediate information transfer between nerve cells. Signal transmission and information processing at synapses control all body functions and all aspects of cognition, including attention, perception, learning, decision making, as well as mood and affect. Since several years it has been recognized that many psychiatric and neurodegenerative disorders are synaptopathies, i.e. pathological conditions where the molecular and cellular pathways operating at the synapse are dysregulated. This scenario is further complicated by the evidence indicating that inflammation has long-term consequences and could speculatively modify the risk and/or severity of a variety of brain diseases. Whether inflammation cascades impact synapse formation and function is not completely defined, although a number of molecules involved in inflammatory processes have been found to regulate specific neuronal processes. The research activity of Laboratory is focused on understanding the molecular mechanisms at the basis of synapse dysfunction and on defining whether key immune molecules impact this process in order to identify new targets suitable for innovative treatments.

Selected publications

Joshi P, Turola E, Ruiz A, Bergami A, Libera DD, Benussi L, Giussani P, Magnani G, Comi G, Legname G, Ghidoni R, Furlan R, Matteoli M*, Verderio C. (2014) Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. (*corresponding) Cell Death Differ. 2014 Apr;21(4):582-93.

E Menna, S Zambetti, R Morini, Aa Donzelli, D Calvigioni, A Disanza, C, V Cappello, G Fossati, C Regondi, C Frassoni, M Francolini, M Sala, G Scita, M Fahnestock and M Matteoli (2013) Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.. EMBO J 12;32(12):1730-44.

Romana Tomasoni, Daniele Repetto, Raffaella Morini, Fabrizio Gardoni, Monica Di Luca, Emilia Turco, Paola Defilippi and Michela Matteoli (2013) SNAP-25 REGULATES SPINE FORMATION THROUGH POSTSYNAPTIC BINDING TO p140Cap. Nature Comm,  19;4:2136.

Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, Riganti L, Corradini I, Francolini M, Garzetti L, Maiorino C, Servida F, Vercelli A, Rocca M, Dalla Libera D, Martinelli V, Comi G, Martino G, Matteoli M, Furlan R. (2012) Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol. 72(4):610-24.

Antonucci F, Kacza J, Caleo M, Verderio C, Giani A, Martens H, Grosche J, Erck C, Hoffmann A, Harkany T,  Matteoli M* and Härtig W (*corresponding author). (2012) Cracking down on inhibition: selective immunolesion of GABAergic neurons. J. Neuroscience, 8;32(6):1989-2001..

Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, Gertler FB, Di Fiore PP, Scita G, Matteoli M. (2009) Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol.7(6):e1000138. Epub 2009 Jun 30

Pozzi D, Condliffe S, Bozzi Y, Chikhladze M, Grumelli C, Proux-Gillardeaux V, Takahashi M, Franceschetti S, Verderio C, Matteoli M.(2008) Activity-dependent  phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels. Proc Natl Acad Sci U S A. 105(1):323-8.

Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urban GM, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T. (2007) Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science. 316 (5828):1212-6

Schenk U, Menna E, Kim T, Passafaro M , Chan S, De Camilli P and Matteoli M (2005) A novel pathway for presynaptic MAPK activation via AMPA receptors. J. Neurosci., 25:1654-63

Verderio C., Pozzi D., Pravettoni E., Inverardi F., Schenk U., Coco S., Proux-Gillardeaux V., Galli T., Rossetto O., Frassoni C. and Matteoli M. (2004) SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization. Neuron, 41: 599-610



Lab Team

Michela Matteoli, PhD, Head of Lab
Irene Corradini, PhD, Post Doc
Chiara Elia, PhD Student (University of Milan, Italy)
Fabia Filipello, PhD, Post Doc
Giuliana Fossati, PhD, Post Doc
Elsa Ghirardini, PhD Student (University of Milan, Italy)
Eliana Laurenzano, PhD, Post Doc
Marta Lombardi, Researcher
Pooja Joshi, PhD, Post Doc
Marialuisa Malosio, PhD, Researcher
Cristina Mantovani, PhD Student (Open University, Milton Keynes, UK)
Elisabetta Menna, PhD, Researcher
Raffaella Morini PhD, Post Doc
Davide Pozzi, Researcher
Marco Rasile, PhD Student (University of Milan, Italy)
Matteo Tamborini, PhD Student (University of Milan, Italy)
Claudia Verderio, PhD, Researcher

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